The cell-death machine
نویسندگان
چکیده
Apoptosis, or programmed cell death, is the physiological process whereby individual cells are deliberately eliminated to achieve homeostasis and proper metazoan development. Numerous genes have recently been identified that are involved in apoptosis: some are believed to encode death effectors, whereas others encode positive or negative regulators of the cell-death machine. Precisely how these various proteins interact in the molecular mechanism of apoptosis remains to be discovered.
منابع مشابه
A stochastic model for the cell formation problem considering machine reliability
This paper presents a new mathematical model to solve cell formation problem in cellular manufacturing systems, where inter-arrival time, processing time, and machine breakdown time are probabilistic. The objective function maximizes the number of operations of each part with more arrival rate within one cell. Because a queue behind each machine; queuing theory is used to formulate the model. T...
متن کاملRobust optimization of a mathematical model to design a dynamic cell formation problem considering labor utilization
Cell formation (CF) problem is one of the most important decision problems in designing a cellular manufacturing system includes grouping machines into machine cells and parts into part families. Several factors should be considered in a cell formation problem. In this work, robust optimization of a mathematical model of a dynamic cell formation problem integrating CF, production planning and w...
متن کاملA Mathematical Model for Integrating Cell Formation Problem with Machine Layout
This paper deals with the cellular manufacturing system (CMS) that is based on group technology concepts. CMS is defined as identifying the similar parts that are processed on the same machines and then grouping them as a cell. The most proposed models for solving CMS are focused on cell formation problem while machine layout is considered in few papers. This paper addresses a mathematical mo...
متن کاملMachine Cell Formation Based on a New Similarity Coefficient
One of the designs of cellular manufacturing systems (CMS) requires that a machine population be partitioned into machine cells. Numerous methods are available for clustering machines into machine cells. One method involves using a similarity coefficient. Similarity coefficients between machines are not absolute, and they still need more attention from researchers. Although there are a number o...
متن کاملDeveloping a cellular manufacturing model considering the alternative routes, tool assignment, and machine reliability
The cell formation (CF) is one of the most important steps in the design of a cellular manufacturing system (CMS), which it includes machines’ grouping in cells and part grouping as separate families, so that the costs are minimized. The various aspects of the problem should be considered in a CF. The machine reliability and the tool assigned to them are the most important problems which have t...
متن کاملImpact of Duration and Severity of Persistent Pain on Programmed Cell Death
Programmed cell death is a highly regulated form of cell death, mostly distinguished by the activation of a family of cystein-aspartate proteases (caspases) that cleave various proteins resulting in morphological and biochemical changes characteristic of this form of cell death. Several recent studies have addressed the role of programmed cell death in inflammatory and chronic pain states. Casp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Current Biology
دوره 6 شماره
صفحات -
تاریخ انتشار 1996